Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141403 | 0.90 | MTOR (0.43) | MTORRPTORMLST8MAPTHTT | |
| SCHEMBL20140814 | 0.89 | MTOR (0.45) | MTORRPTORMLST8EEDALDH1A1 | |
| SCHEMBL20141023 | 0.88 | EED (0.45) | EEDALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL20141228 | 0.88 | MTOR (0.45) | MTORRPTORMLST8EEDLMNA | |
| SCHEMBL20141317 | 0.87 | MTOR (0.46) | MTORRPTORMLST8MAPTHTT | |
| SCHEMBL20141169 | 0.86 | MTOR (0.45) | MTORRPTORMLST8ALDH1A1MAPT | |
| SCHEMBL20140851 | 0.85 | MTOR (0.44) | MTORRPTORMLST8ALDH1A1MAPT | |
| SCHEMBL20141024 | 0.85 | MTOR (0.46) | MTORRPTORMLST8EEDALDH1A1 | |
| SCHEMBL20141263 | 0.84 | MTOR (0.46) | MTORRPTORMLST8MAPTHTT | |
| SCHEMBL20140929 | 0.82 | MTOR (0.57) | MTORRPTORMLST8ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |