Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.47 |
| ▸ | PARP3 | Q9Y6F1 | 4/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141473 | 0.92 | MTOR (0.50) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140597 | 0.90 | MTOR (0.43) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20142366 | 0.87 | MTOR (0.46) | PARP1MTORRPTORMLST8DRD2 | |
| SCHEMBL20140795 | 0.86 | MTOR (0.58) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140622 | 0.85 | MTOR (0.43) | PARP1MTORRPTORMLST8DRD2 | |
| SCHEMBL20139883 | 0.83 | MTOR (0.54) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20139999 | 0.82 | DRD4 (0.48) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20156981 | 0.80 | MTOR (0.58) | PARP1MTORRPTORMLST8KDM4E | |
| SCHEMBL20140616 | 0.79 | DRD4 (0.45) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140146 | 0.78 | KDM4E (0.53) | PARP1MTORRPTORMLST8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |