Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 7/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141473 | 0.90 | MTOR (0.50) | MTORRPTORMLST8PARP1DPP4 | |
| SCHEMBL20157126 | 0.89 | MTOR (0.48) | MTORRPTORMLST8PARP1RET | |
| SCHEMBL20140010 | 0.89 | MTOR (0.44) | MTORRPTORMLST8PARP1RET | |
| SCHEMBL20142366 | 0.85 | MTOR (0.46) | MTORRPTORMLST8PARP1DPP4 | |
| Trifluoroacetic Acid SCHEMBL20140494 | 0.85 | PPARG (0.46) | MTORRPTORMLST8PARP1RET | |
| SCHEMBL20141355 | 0.85 | PARP1 (0.50) | MTORRPTORMLST8PARP1DRD2 | |
| SCHEMBL20157251 | 0.82 | PARP1 (0.49) | MTORRPTORMLST8PARP1PRKAA2 | |
| SCHEMBL20140597 | 0.82 | MTOR (0.43) | MTORRPTORMLST8PARP1DPP4 | |
| SCHEMBL20139999 | 0.81 | DRD4 (0.48) | MTORRPTORMLST8PARP1DPP4 | |
| SCHEMBL20140669 | 0.81 | PARP1 (0.45) | MTORRPTORMLST8PARP1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |