Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140200 | 0.92 | MTOR (0.59) | DRD2DRD4DRD3THRBMTOR | |
| SCHEMBL20139905 | 0.90 | DRD2 (0.54) | DRD2DRD4DRD3THRBHTR7 | |
| SCHEMBL20139962 | 0.89 | MTOR (0.55) | DRD2DRD4DRD3MTORRPTOR | |
| SCHEMBL20156918 | 0.89 | MTOR (0.55) | DRD2DRD4DRD3MTORRPTOR | |
| SCHEMBL20140235 | 0.88 | MTOR (0.67) | DRD2DRD4DRD3HTR7MTOR | |
| SCHEMBL20139928 | 0.88 | MTOR (0.56) | DRD2DRD4DRD3MTORRPTOR | |
| SCHEMBL20156824 | 0.88 | MTOR (0.56) | DRD2DRD4DRD3MTORRPTOR | |
| SCHEMBL20140824 | 0.88 | MTOR (0.67) | DRD2DRD4DRD3HTR7MTOR | |
| SCHEMBL20140246 | 0.87 | MTOR (0.57) | DRD2DRD4DRD3MTORRPTOR | |
| SCHEMBL20140719 | 0.87 | MTOR (0.57) | DRD2DRD4DRD3MTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |