Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141102 | 0.83 | POLB (0.54) | LMNAMAPTALDH1A1 | |
| SCHEMBL21384410 | 0.77 | KDM4E (0.47) | HSD11B1SMN1; SMN2LMNATSHRL3MBTL1 | |
| SCHEMBL2335427 | 0.77 | GAA (0.47) | HSD11B1RBP4SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL20140399 | 0.76 | KMT2A (0.53) | NPC1HSD11B1RBP4SMN1; SMN2LMNA | |
| SCHEMBL20140801 | 0.75 | NPC1 (0.41) | NPC1HSD11B1RBP4SMN1; SMN2LMNA | |
| SCHEMBL2217096 | 0.74 | HTR2A (0.60) | TSHRL3MBTL1GAAKDM4EHSD17B10 | |
| SCHEMBL2716180 | 0.72 | NPC1 (0.47) | NPC1SMN1; SMN2LMNATSHRL3MBTL1 | |
| SCHEMBL20339483 | 0.71 | TRPV1 (0.61) | HSD11B1GAAKMT2AALDH1A1 | |
| SCHEMBL4524859 | 0.70 | NPY5R (0.52) | SMN1; SMN2TSHRKDM4EHSD17B10MEN1 | |
| SCHEMBL122835 | 0.70 | KMT2A (0.47) | HSD11B1RBP4GAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |