Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.73 |
| ▸ | ITGAV | P06756 | 20/20 | 0.73 |
| ▸ | ITGB5 | P18084 | 16/20 | 0.73 |
| ▸ | ITGB6 | P18564 | 16/20 | 0.73 |
| ▸ | ITGB8 | P26012 | 16/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141300 | 0.88 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL20141298 | 0.88 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL20157744 | 0.85 | ITGAV (0.69) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL27132661 | 0.84 | ITGAV (0.66) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL29162823 | 0.84 | ITGAV (0.66) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL27003189 | 0.84 | ITGAV (0.66) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL20141596 | 0.84 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL20141599 | 0.84 | ITGAV (0.68) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL21317464 | 0.83 | ITGAV (0.66) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL20142624 | 0.83 | ITGB3 (0.66) | ITGB3ITGAVITGB5ITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | claimed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | claimed |