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SCHEMBL20141913

SCHEMBL20141913

COC(=O)C1CN(C(=O)OC(C)(C)C)CCN1c1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 2/20 0.46
▸ HDAC2 Q92769 2/20 0.46
▸ MMP13 P45452 1/20 0.43
▸ MMP1 P03956 1/20 0.43
▸ MMP3 P08254 1/20 0.43
▸ MMP7 P09237 1/20 0.43
▸ MMP9 P14780 1/20 0.43
▸ GRM5 P41594 1/20 0.42
▸ GRM1 Q13255 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ GPR119 Q8TDV5 2/20 0.42
▸ POLB P06746 1/20 0.42
▸ NR1H2 P55055 1/20 0.41
▸ NR1H3 Q13133 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ PTPN2 P17706 1/20 0.41
▸ PTPN1 P18031 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21340083 1.00 HDAC1 (0.46) HDAC1HDAC2MMP13MMP1MMP3
SCHEMBL13923464 0.88 MAPT (0.52) MMP13MMP1MMP3MMP7MMP9
SCHEMBL1017433 0.88 MEN1 (0.50) MMP1MMP3MMP7MMP9ALDH1A1
SCHEMBL653759 0.88 MEN1 (0.50) MMP1MMP3MMP7MMP9ALDH1A1
SCHEMBL16731904 0.88 GPR119 (0.52) MMP1MMP3MMP7MMP9ALDH1A1
SCHEMBL21360316 0.88 GPR119 (0.52) MMP1MMP3MMP7MMP9ALDH1A1
SCHEMBL20142381 0.88 GPR119 (0.52) MMP1MMP3MMP7MMP9ALDH1A1
SCHEMBL20142045 0.88 MEN1 (0.46) HDAC1HDAC2MMP13GRM5GRM1
SCHEMBL5384801 0.88 MEN1 (0.46) HDAC1HDAC2MMP13GRM5GRM1
SCHEMBL5395589 0.87 GPR119 (0.42) HDAC1HDAC2MMP13GRM5GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR HDAC1 286/4885HDAC2 339/4885MMP13 4178/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR HDAC1 286/4885HDAC2 339/4885MMP13 4178/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR HDAC1 286/4885HDAC2 339/4885MMP13 4178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.