Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.71 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.71 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.71 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133674 | 1.00 | MTOR (0.71) | MTORRPTORMLST8GRM1GPR6 | |
| SCHEMBL22693226 | 0.92 | MTOR (0.83) | MTORRPTORMLST8GRM1GPR6 | |
| SCHEMBL20133657 | 0.91 | MTOR (0.84) | MTORRPTORMLST8GPR6DRD4 | |
| SCHEMBL22187975 | 0.84 | MTOR (0.75) | MTORRPTORMLST8GPR6PHGDH | |
| SCHEMBL20133547 | 0.84 | MTOR (0.75) | MTORRPTORMLST8GPR6PHGDH | |
| SCHEMBL20133676 | 0.83 | MTOR (0.74) | MTORRPTORMLST8GPR6PHGDH | |
| SCHEMBL20133659 | 0.83 | MTOR (0.74) | MTORRPTORMLST8GPR6PHGDH | |
| SCHEMBL20133671 | 0.83 | MTOR (1.00) | MTORRPTORMLST8GPR6 | |
| SCHEMBL22188079 | 0.82 | MTOR (0.73) | MTORRPTORMLST8GPR6PHGDH | |
| SCHEMBL20142672 | 0.82 | MTOR (0.50) | MTORRPTORMLST8GRM1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |