Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142669 | 1.00 | MTOR (0.50) | MTORRPTORMLST8GRM1CA12 | |
| SCHEMBL20140280 | 0.89 | GRM1 (0.45) | MTORRPTORMLST8GRM1GFER | |
| SCHEMBL20142818 | 0.89 | GRM1 (0.45) | MTORRPTORMLST8GRM1GFER | |
| SCHEMBL20140914 | 0.88 | MTOR (0.47) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140779 | 0.86 | GRM1 (0.42) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140416 | 0.86 | GRM1 (0.43) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20157190 | 0.85 | GRM1 (0.47) | MTORRPTORMLST8GRM1NAMPT | |
| SCHEMBL20140821 | 0.85 | MTOR (0.45) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20140823 | 0.85 | MTOR (0.45) | MTORRPTORMLST8GRM1DRD4 | |
| SCHEMBL20157448 | 0.85 | GRM1 (0.47) | MTORRPTORMLST8GRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |