Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142139 | 1.00 | ADORA3 (0.41) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL20142339 | 0.83 | ADORA3 (0.44) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL20142338 | 0.83 | ADORA3 (0.44) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL174160 | 0.77 | ATM (0.54) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL5476235 | 0.75 | ADORA3 (0.52) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL2883924 | 0.74 | ADORA3 (0.46) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL2883929 | 0.74 | ADORA3 (0.46) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL8220418 | 0.74 | ADORA3 (0.46) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL2883926 | 0.74 | ADORA3 (0.46) | ADORA3KCNH2ATMPDE5AMAPT | |
| SCHEMBL20161116 | 0.74 | ATM (0.48) | ADORA3KCNH2ATMPDE5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538520-A2 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |