Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142261 | 0.85 | MTOR (0.51) | MTORRPTORMLST8THRBKDM4E | |
| SCHEMBL20133713 | 0.83 | MTOR (0.55) | MTORRPTORMLST8THRBDRD4 | |
| SCHEMBL20133694 | 0.80 | MTOR (0.54) | MTORRPTORMLST8THRBDRD2 | |
| SCHEMBL20133693 | 0.78 | MTOR (0.54) | MTORRPTORMLST8THRBDRD2 | |
| SCHEMBL20129666 | 0.76 | MTOR (0.62) | MTORRPTORMLST8THRBDRD2 | |
| SCHEMBL20141071 | 0.76 | MTOR (0.53) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20140924 | 0.76 | MTOR (0.55) | MTORRPTORMLST8THRBDRD2 | |
| SCHEMBL20129637 | 0.76 | MTOR (0.64) | MTORRPTORMLST8THRBDRD2 | |
| SCHEMBL20133777 | 0.76 | MTOR (0.52) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20129693 | 0.74 | MTOR (0.61) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |