Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.84 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.84 |
| ▸ | TUBB | P07437 | 1/20 | 0.84 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.84 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.84 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.84 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.84 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.84 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.84 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.84 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.84 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.76 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142406 | 0.91 | TUBB8B (1.00) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL30899249 | 0.91 | TUBB8B (1.00) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL20142441 | 0.90 | TUBB8B (0.85) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL20142176 | 0.89 | TUBB8B (0.84) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL4477198 | 0.89 | MEN1 (1.00) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL4395515 | 0.88 | MEN1 (0.88) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL4393604 | 0.88 | MEN1 (0.88) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL4398263 | 0.86 | CDK5 (0.72) | MEN1KMT2AMAPTTP53CDK5 | |
| SCHEMBL20142433 | 0.85 | MEN1 (0.72) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 | |
| SCHEMBL20142148 | 0.83 | GSK3A (0.73) | TUBB8BTUBB4ATUBBTUBB4BTUBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |