TUBB8B

Tubulin beta 8B · A6NNZ2 · TUBB8B on Sugi Atlas →

1,387 patent compounds predicted against TUBB8B, 1,188 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL682440 SCHEMBL682440 0.71 4/20
SCHEMBL685342 SCHEMBL685342 0.55 4/20
SCHEMBL682409 SCHEMBL682409 0.54 4/20
SCHEMBL12337064 SCHEMBL12337064 0.45 4/20
Noscapine Noscapine (SCHEMBL8362337) 0.73 3/20
Noscapine Noscapine (SCHEMBL10701499) 0.70 3/20
SCHEMBL676698 SCHEMBL676698 0.70 3/20
SCHEMBL676699 SCHEMBL676699 0.70 3/20
SCHEMBL12635400 SCHEMBL12635400 0.70 3/20
SCHEMBL682444 SCHEMBL682444 0.68 3/20
SCHEMBL682418 SCHEMBL682418 0.62 3/20
SCHEMBL6239031 SCHEMBL6239031 0.56 3/20
SCHEMBL10873510 SCHEMBL10873510 0.52 3/20
SCHEMBL682197 SCHEMBL682197 0.50 3/20
SCHEMBL6239139 SCHEMBL6239139 0.74 2/20
Noscapine Noscapine (SCHEMBL5981606) 0.70 2/20
SCHEMBL6246498 SCHEMBL6246498 0.68 2/20
SCHEMBL12337063 SCHEMBL12337063 0.55 2/20
SCHEMBL681552 SCHEMBL681552 0.53 2/20
SCHEMBL10073422 SCHEMBL10073422 0.53 2/20

Clinical trials — most relevant to TUBB8B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) PHASE2/PHASE3ACTIVE_NOT_RECRUITING
Four Versus Six Cycles of Cyclophosphamide/Doxorubicin or Paclitaxel in Adjuvant Breast Cancer PHASE3COMPLETED
Vinorelbine in Relapsed Platinum Resistant or Refractory C5 High Grade Serous, Endometrioid, or Undifferentiated Primary Peritoneum, Fallopian Tube or Ovarian Cancer PHASE2UNKNOWN
Biologic Correlative Taxotere/AC PHASE2COMPLETED
A Multicenter Study of NAP (AL-108) in Schizophrenia PHASE2COMPLETED
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer PHASE2COMPLETED
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis PHASE1/PHASE2WITHDRAWN
Therapy With Docetaxel and ZD1839 for Patients Who Have Advanced Breast Cancer PHASE2COMPLETED
Study of ABT-751 in Patients With Refractory Hematologic Malignancies PHASE1COMPLETED
Treating Patients With Advanced Solid Tumors, Breast Cancer or Recurrent Ovarian Cancer PHASE1COMPLETED
SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes PHASE1COMPLETED
Phase I Study of Oral BAY 1217389 in Combination With Intravenous Paclitaxel PHASE1COMPLETED
Exploratory Evaluation of [11C]MPC6827 EARLY_PHASE1COMPLETED
Mapping Disease Pathways for Biliary Atresia nanRECRUITING
Diagnostic of Chemotherapy Induced Neuropathy in Children nanCOMPLETED
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
The Relation of Microtubule-Associated Protein 2 and Cell Migration nanUNKNOWN
Genetics of Primary Ciliary Dyskinesia nanCOMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
Myotubular Myopathy Genetic Testing Study nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity nanCOMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Prostate Cancer Antigen 3 (PCA-3) Gene Project nanCOMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
Biomarkers and Validation of Selected Outcome Measures (CMTBiomarker) nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TUBB8B binder may also engage these)

ProteinNameSimilarity
P46265 1.000 P46265 →
Q6B856 1.000 Q6B856 →
TUBB2B Tubulin beta-2B chain 1.000 landscape →
P69893 1.000 P69893 →
P11833 1.000 P11833 →
Q3MHM5 1.000 Q3MHM5 →
P68372 1.000 P68372 →
Q4R4X8 1.000 Q4R4X8 →
Q6GLE7 1.000 Q6GLE7 →
O44388 1.000 O44388 →
TUBB2A Tubulin beta-2A chain 1.000 landscape →
P85108 1.000 P85108 →
Q2HJ81 1.000 Q2HJ81 →
Q5R943 1.000 Q5R943 →
Q8WP14 1.000 Q8WP14 →
Q27U48 1.000 Q27U48 →
Q91240 1.000 Q91240 →
P61858 1.000 P61858 →
TUBB8 Tubulin beta-8 chain 1.000 landscape →
O59837 1.000 O59837 →
P12456 1.000 P12456 →
Q9YHC3 1.000 Q9YHC3 →
Q9NFZ7 1.000 Q9NFZ7 →
TUBB4A Tubulin beta-4A chain 1.000 landscape →
P69897 1.000 P69897 →
Q7JJU6 1.000 Q7JJU6 →
P14140 1.000 P14140 →
Q91575 1.000 Q91575 →
P99024 1.000 P99024 →
P20365 1.000 P20365 →