Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.58 |
| ▸ | ITGB6 | P18564 | 6/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.58 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29701412 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20141068 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL29702241 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL29701362 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20142807 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20141069 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20142806 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20142799 | 1.00 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20157778 | 0.92 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL30487517 | 0.92 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGA2BITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-B1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-04-10 | — | — | EP | claimed |
| CN-110167934-B | Cyclobutane-and azetidine-containing monocyclic and spiro compounds as alpha V integrin inhibitors | 百时美施贵宝公司 | 2022-06-10 | — | — | CN | claimed |
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | claimed |
| US-20190270741-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-05 | — | — | US | claimed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190270741-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | ITGB1, ITGAV, ITGA1 | ITGAV 2/4885ITGB3 8/4885ITGB6 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.