Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.58 |
| ▸ | GSK3A | P49840 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142928 | 1.00 | GSK3B (0.58) | GSK3BGSK3AMAPTGRM5ACKR3 | |
| SCHEMBL20138846 | 0.85 | GSK3A (0.56) | GSK3BGSK3AMAPTGRM5NPC1 | |
| SCHEMBL20138847 | 0.85 | GSK3A (0.56) | GSK3BGSK3AMAPTGRM5NPC1 | |
| SCHEMBL18208170 | 0.81 | GSK3B (0.58) | GSK3BGSK3AMAPTACVRL1ABL1 | |
| SCHEMBL18208167 | 0.81 | GSK3B (0.58) | GSK3BGSK3AMAPTACVRL1ABL1 | |
| SCHEMBL20138997 | 0.78 | KDM4E (0.49) | GSK3BGSK3AMAPTNPC1RAB9A | |
| SCHEMBL20138994 | 0.78 | KDM4E (0.49) | GSK3BGSK3AMAPTNPC1RAB9A | |
| SCHEMBL18216490 | 0.77 | GSK3B (0.51) | GSK3BGSK3AMAPTABL1 | |
| SCHEMBL20138808 | 0.76 | GSK3A (0.48) | GSK3BGSK3AABL1 | |
| SCHEMBL20138806 | 0.76 | GSK3A (0.48) | GSK3BGSK3AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |