Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16398842 | 0.86 | NPC1 (0.49) | NPC1RAB9AFAAHTRPV1ALPL | |
| SCHEMBL247644 | 0.84 | NPC1 (0.37) | NPC1RAB9ALMNATP53MEN1 | |
| SCHEMBL13884156 | 0.80 | MAPK8 (0.39) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL16586735 | 0.78 | MAPK8 (0.38) | NPC1RAB9ALMNATP53MEN1 | |
| SCHEMBL16586570 | 0.77 | NPC1 (0.36) | NPC1RAB9ALMNATP53MEN1 | |
| SCHEMBL10164748 | 0.76 | MAPK8 (0.41) | NPC1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL10164591 | 0.76 | MAPK8 (0.36) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL14834162 | 0.74 | SETDB1 (0.36) | LMNATP53MEN1KMT2A | |
| SCHEMBL15186069 | 0.73 | CFD (0.36) | NPC1RAB9ALMNAMEN1HPGD | |
| SCHEMBL14834082 | 0.73 | KMT2A (0.40) | LMNAMEN1KMT2ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969734-B2 | Process for the preparation of spiroheterocyclic pyrrolidine diones | SYNGENTA PARTICIPATIONS AG (CH) | 2018-05-15 | — | — | US | disclosed |