Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.79 |
| ▸ | EGFR | P00533 | 4/20 | 0.69 |
| ▸ | LCK | P06239 | 2/20 | 0.69 |
| ▸ | ITK | Q08881 | 2/20 | 0.69 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.58 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144230 | 0.91 | BTK (0.84) | BTKEGFRLCKITK | |
| SCHEMBL20144259 | 0.90 | BTK (0.83) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL2157185 | 0.90 | BTK (0.82) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL410037 | 0.90 | BTK (0.82) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL16074971 | 0.88 | BTK (1.00) | BTKEGFRLCKITK | |
| SCHEMBL20144258 | 0.86 | BTK (0.79) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL20144243 | 0.86 | BTK (0.64) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL2158182 | 0.85 | BTK (0.91) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL410025 | 0.85 | BTK (0.91) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL20144254 | 0.85 | BTK (0.80) | BTKEGFRLCKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970300-B1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-05-16 | — | — | EP | disclosed |