Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145082 | 0.91 | HCRTR1 (0.45) | HCRTR1HCRTR2PHGDHKMT2AMEN1 | |
| SCHEMBL20145022 | 0.90 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL18697657 | 0.80 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20145007 | 0.80 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL18697767 | 0.77 | HCRTR1 (0.72) | HCRTR1HCRTR2 | |
| SCHEMBL20144987 | 0.77 | HCRTR1 (0.72) | HCRTR1HCRTR2 | |
| SCHEMBL20144729 | 0.77 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL20145031 | 0.75 | HCRTR2 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20145056 | 0.75 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20144723 | 0.75 | HCRTR1 (0.70) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |