Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144870 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2RIPK1PROKR1 | |
| SCHEMBL20145036 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2RIPK1PROKR1 | |
| SCHEMBL20144793 | 0.81 | HCRTR1 (0.51) | HCRTR1HCRTR2RIPK1 | |
| SCHEMBL20144876 | 0.80 | HCRTR1 (0.69) | HCRTR1HCRTR2RIPK1PROKR1 | |
| SCHEMBL20144950 | 0.79 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL18697848 | 0.79 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL18697566 | 0.78 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL20145015 | 0.78 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL20145019 | 0.76 | HCRTR1 (0.55) | HCRTR1HCRTR2RIPK1 | |
| SCHEMBL20144790 | 0.74 | HCRTR1 (0.53) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |