Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18607845 | 0.84 | PDGFRB (0.41) | ALOX5APFEN1 | |
| SCHEMBL31239631 | 0.74 | HCRTR1 (0.33) | ALOX5APFEN1 | |
| SCHEMBL25145541 | 0.74 | HCRTR1 (0.33) | ALOX5APFEN1 | |
| SCHEMBL31239665 | 0.73 | HCRTR1 (0.34) | KCNH2 | |
| SCHEMBL25936181 | 0.73 | HCRTR1 (0.34) | KCNH2 | |
| SCHEMBL20144981 | 0.73 | IL1B (0.46) | — | |
| SCHEMBL20145101 | 0.73 | IL1B (0.46) | — | |
| SCHEMBL22686947 | 0.73 | CHEK1 (0.45) | CHRNB2CHRNA4CHEK1ROCK1ROCK2 | |
| SCHEMBL18072443 | 0.73 | CHEK1 (0.45) | CHRNB2CHRNA4CHEK1ROCK1ROCK2 | |
| SCHEMBL18072335 | 0.73 | CHEK1 (0.45) | CHRNB2CHRNA4CHEK1ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |