IL1B — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1019948	0.69	18/20
SCHEMBL1020677	0.69	18/20
SCHEMBL1020218	0.67	18/20
SCHEMBL1020097	0.67	18/20
SCHEMBL1021216	0.65	18/20
SCHEMBL1020257	0.64	18/20
SCHEMBL1020259	0.63	18/20
SCHEMBL1023079	0.63	18/20
SCHEMBL1019994	0.63	18/20
SCHEMBL1019477	0.62	18/20
SCHEMBL1019339	0.56	18/20
SCHEMBL1020208	0.81	17/20
SCHEMBL1018984	0.66	17/20
SCHEMBL1019225	0.66	17/20
SCHEMBL1019676	0.66	17/20
SCHEMBL1020307	0.66	17/20
SCHEMBL1020579	0.66	17/20
SCHEMBL1019555	0.64	17/20
SCHEMBL1020744	0.62	17/20
SCHEMBL1019240	0.60	17/20

Clinical trials — most relevant to IL1B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Amantadine for COVID-19	PHASE3	UNKNOWN
Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to Covid-19 (ANA-COVID-GEAS)	PHASE2/PHASE3	COMPLETED
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass	PHASE2/PHASE3	COMPLETED
Colchicine and Inflammation in Hemodialysis Patients	PHASE2	UNKNOWN
Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant	PHASE2	COMPLETED
Effectiveness of Ashwagandha in Schizophrenia Patients on Risperidone	PHASE2	COMPLETED
Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Therapy	PHASE1/PHASE2	UNKNOWN
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders	nan	UNKNOWN
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Acupuncture for Reduction of Inflammation	nan	COMPLETED
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
The Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia	nan	NOT_YET_RECRUITING
Interleukin-34 in Stage I and II Periodontitis	nan	COMPLETED
Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions	nan	RECRUITING
Corticosteroid Treatment for Acute Respiratory Distress Syndrome	nan	COMPLETED
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF	nan	NOT_YET_RECRUITING
The Association of Resistance Exercise With the Inflammasome Activation in Obesity Subjects	nan	UNKNOWN
The White Blood Cell Reactivity Following Surgical Trauma and Associated Regulatory Mechanisms.	nan	COMPLETED
Post-surgery Systemic Inflammation and Neuro-immune Interactions	nan	COMPLETED
Macrolide Mediates Pulmonary Infection of Pseudomonas Aeruginosa	nan	COMPLETED
Inflammatory Cytokines in GCF and Placental Tissues in Chronic Periodontitis Patients With Preterm Delivery	nan	COMPLETED
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support	nan	UNKNOWN
Clinical Phenotypes in Pericarditis: IL-1RA Antibodies and suPAR Levels	nan	RECRUITING
Early Regenerative Intervention for Post-Traumatic Osteoarthritis	nan	UNKNOWN
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients	nan	COMPLETED
Genetic Polymorphisms Associated With CAD	nan	UNKNOWN
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.	nan	UNKNOWN
Study to Evaluate the Effect of Botanical Dietary Supplements on Inflammation in Healthy People	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a IL1B binder may also engage these)

Protein	Name	Similarity
P79182	—	1.000	P79182 →
P46648	—	1.000	P46648 →
Q28386	—	1.000	Q28386 →
Q2HZH0	—	1.000	Q2HZH0 →
P21621	—	1.000	P21621 →
P79162	—	1.000	P79162 →
Q2MH07	—	1.000	Q2MH07 →
P09428	—	1.000	P09428 →
Q28292	—	1.000	Q28292 →
P51745	—	1.000	P51745 →
Q63264	—	1.000	Q63264 →
P51493	—	1.000	P51493 →
P41687	—	1.000	P41687 →
Q6R2X3	—	1.000	Q6R2X3 →
Q6PUD2	—	1.000	Q6PUD2 →
P14628	—	1.000	P14628 →
P10749	—	0.999	P10749 →
A4UYK8	—	0.999	A4UYK8 →
Q865X8	—	0.998	Q865X8 →
P48090	—	0.998	P48090 →
Q9WVG1	—	0.998	Q9WVG1 →
P26889	—	0.997	P26889 →
Q8WNR2	—	0.996	Q8WNR2 →
P04822	—	0.993	P04822 →
Q9XS77	—	0.991	Q9XS77 →
O46613	—	0.990	O46613 →
P08831	—	0.988	P08831 →
Q9YGD3	—	0.988	Q9YGD3 →
Q3HWU1	—	0.988	Q3HWU1 →
Q28385	—	0.987	Q28385 →