Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 7/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | DCPS | Q96C86 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18109548 | 0.81 | TLR8 (0.45) | TLR8ADORA2APIK3CG | |
| SCHEMBL22368547 | 0.81 | TLR8 (0.45) | TLR8DHFR | |
| SCHEMBL10375776 | 0.80 | DHFR (0.42) | DHFRADORA2ADCPSPIK3CG | |
| SCHEMBL22539043 | 0.78 | TLR8 (0.54) | TLR8 | |
| SCHEMBL22256188 | 0.77 | HTT (0.45) | DHFRADORA2ADCPSPIK3CG | |
| SCHEMBL20780662 | 0.77 | CCR1 (0.45) | TLR8DHFRADORA2A | |
| SCHEMBL1219738 | 0.77 | TLR8 (0.44) | TLR8DHFRADORA2APIK3CG | |
| SCHEMBL2776658 | 0.74 | MAP4K4 (0.44) | — | |
| SCHEMBL30682757 | 0.74 | TLR8 (0.40) | TLR8DHFR | |
| SCHEMBL22854319 | 0.74 | TLR8 (0.63) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264081-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| EP-3722297-A1 | TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS | Gilead Sciences, Inc. (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |