Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 16/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | MERTK | Q12866 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145422 | 0.87 | MAPK1 (0.79) | MAPK1 | |
| SCHEMBL16679297 | 0.82 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL16679296 | 0.82 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL20145640 | 0.80 | MAPK1 (0.68) | MAPK1 | |
| SCHEMBL20145591 | 0.79 | MAPK1 (0.70) | MAPK1 | |
| SCHEMBL16679358 | 0.76 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL20145780 | 0.76 | MAPK1 (0.74) | MAPK1 | |
| SCHEMBL3461899 | 0.76 | ATR (0.68) | MAPK1 | |
| SCHEMBL16680183 | 0.74 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL20145526 | 0.73 | MAPK1 (0.86) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |