Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 17/20 | 0.68 |
| ▸ | ATR | Q13535 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16679751 | 0.81 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL16679747 | 0.81 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL20145591 | 0.81 | MAPK1 (0.70) | MAPK1HPGDSROCK2RPS6KA5MAP4K4 | |
| SCHEMBL20145662 | 0.80 | MAPK1 (0.70) | MAPK1 | |
| SCHEMBL16680183 | 0.76 | MAPK1 (1.00) | MAPK1HPGDSROCK2RPS6KA5MAP4K4 | |
| SCHEMBL3461899 | 0.75 | ATR (0.68) | MAPK1ATRHPGDS | |
| SCHEMBL2934942 | 0.74 | ALDH1A1 (0.53) | MAPK1ATR | |
| SCHEMBL1679733 | 0.73 | LDHA (0.54) | MAPK1ATRHPGDSROCK2MAP4K4 | |
| SCHEMBL3460691 | 0.72 | LDHA (0.52) | MAPK1ATRHPGDSMAP4K4PRKCG | |
| SCHEMBL3459712 | 0.72 | LDHA (0.63) | ATRHPGDSMAP4K4PRKCGROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |