Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 8/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145794 | 0.84 | AKT2 (0.55) | NEK2AKT2ALDH1A1HSD17B10 | |
| SCHEMBL20145894 | 0.82 | MAP4K4 (0.52) | CYP46A1NEK2ATRPDE10AAKT2 | |
| SCHEMBL22240433 | 0.79 | UBE2N (0.54) | ATR | |
| SCHEMBL19801719 | 0.74 | RPS6KB1 (0.42) | AKT2RPS6KB1BTK | |
| SCHEMBL14334180 | 0.73 | MALT1 (0.52) | CYP46A1NEK2PDE10AALDH1A1 | |
| SCHEMBL22240510 | 0.72 | BTK (0.47) | NEK2BTK | |
| SCHEMBL25668037 | 0.72 | NEK2 (0.49) | NEK2BTK | |
| SCHEMBL16786557 | 0.72 | BTK (0.41) | BTK | |
| SCHEMBL16786552 | 0.72 | BTK (0.41) | BTK | |
| SCHEMBL20862434 | 0.72 | MAP4K4 (0.48) | PIK3CDRPS6KB1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858499-B1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | BIOGEN MA INC (US) | 2018-05-16 | — | — | EP | disclosed |