Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 5/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145794 | 0.84 | AKT2 (0.55) | RXFP1NEK2ALDH1A1MAPTHPGD | |
| SCHEMBL20145802 | 0.82 | CYP46A1 (0.47) | CYP46A1NEK2ATRRPS6KB1BTK | |
| SCHEMBL22240433 | 0.79 | UBE2N (0.54) | MAP4K4RXFP1ATRCHRM4MAPT | |
| SCHEMBL19801719 | 0.74 | RPS6KB1 (0.42) | RPS6KB1BTKAKT2 | |
| SCHEMBL14334510 | 0.73 | MALT1 (0.60) | RXFP1CYP46A1NEK2PDE10A | |
| SCHEMBL25668037 | 0.72 | NEK2 (0.49) | NEK2BTK | |
| SCHEMBL22240510 | 0.72 | BTK (0.47) | NEK2BTK | |
| SCHEMBL16786552 | 0.72 | BTK (0.41) | BTK | |
| SCHEMBL20862434 | 0.72 | MAP4K4 (0.48) | MAP4K4RPS6KB1BTK | |
| SCHEMBL20862481 | 0.71 | PIK3CA (0.52) | RPS6KB1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753934-A1 | PYRIMIDINYL DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | Biogen MA Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2858499-B1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | BIOGEN MA INC (US) | 2018-05-16 | — | — | EP | disclosed |