Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5633033 | 0.87 | USP2 (0.58) | USP2ALDH1A1KDM4EMAPTCYP3A4 | |
| Lithium Ion SCHEMBL5633232 | 0.85 | USP2 (0.57) | USP2ALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL17538382 | 0.81 | CYP3A4 (0.58) | USP2ALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL13875589 | 0.80 | USP2 (0.63) | USP2ALDH1A1MAPTCYP3A4CYP2D6 | |
| SCHEMBL8253693 | 0.80 | USP2 (0.59) | USP2ALDH1A1MAPTCYP3A4CYP2D6 | |
| SCHEMBL29152989 | 0.79 | USP2 (0.66) | USP2ALDH1A1MAPTCYP3A4CYP2D6 | |
| SCHEMBL16372562 | 0.79 | USP2 (0.66) | USP2ALDH1A1MAPTCYP3A4CYP2D6 | |
| SCHEMBL11201625 | 0.78 | USP2 (0.58) | USP2ALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL2203631 | 0.78 | USP2 (0.53) | USP2ALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL829129 | 0.76 | USP2 (0.52) | USP2ALDH1A1KDM4EMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3320922-A1 | METHODS FOR MODULATING KALLIKREIN (KLKB1) EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |