Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5633033 | 0.98 | USP2 (0.58) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL13875589 | 0.91 | USP2 (0.63) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL8253693 | 0.91 | USP2 (0.59) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL29152989 | 0.89 | USP2 (0.66) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL16372562 | 0.89 | USP2 (0.66) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL2203631 | 0.87 | USP2 (0.53) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL829129 | 0.86 | USP2 (0.52) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL20146158 | 0.85 | USP2 (0.49) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL11201625 | 0.84 | USP2 (0.58) | USP2ALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL12153235 | 0.84 | USP2 (0.58) | USP2ALDH1A1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297708-B2 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-20 | — | — | US | disclosed |
| US-20030229091-A1 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-11 | — | — | US | disclosed |
| WO-2003022820-A1 | HETEROAROMATIC SUBSTITUTED CYCLOPROPANE AS CORTICOTROPIN RELEASING HORMONE | BRISTOL-MYERS SQUIBB PHARMA COMPANY. (US) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229091-A1 | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands | CRHR1, CRH, CRHR2 | USP2 1983/4885ALDH1A1 2218/4885MEN1 2646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.