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Sugi Predict / Compounds / SCHEMBL2014651

SCHEMBL2014651

SCHEMBL2014651

CC(O)c1cc(Cl)c2ccncc2c1-c1cccc(F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 2/20 0.39
▸ BCL2 P10415 1/20 0.39
▸ CSNK2A2 P19784 1/20 0.39
▸ CSNK2B P67870 1/20 0.39
▸ DGAT2 Q96PD7 3/20 0.37
▸ SLC22A12 Q96S37 1/20 0.36
▸ JAK2 O60674 2/20 0.35
▸ NT5E P21589 1/20 0.35
▸ CYP17A1 P05093 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP11B1 P15538 1/20 0.34
▸ CYP11B2 P19099 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ GRIN2B Q13224 1/20 0.33
▸ GCGR P47871 1/20 0.33
▸ GRM5 P41594 1/20 0.33
▸ MAPK13 O15264 1/20 0.33
▸ MAPK12 P53778 1/20 0.33
▸ MAPK11 Q15759 1/20 0.33
▸ MAPK14 Q16539 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2015153 0.88 BCL2 (0.41) PIK3CDBCL2CSNK2A2CSNK2BDGAT2
SCHEMBL12470054 0.85 PIK3CD (0.38) PIK3CDBCL2CSNK2A2CSNK2BDGAT2
SCHEMBL15621376 0.85 PIK3CD (0.38) PIK3CDBCL2CSNK2A2CSNK2BDGAT2
SCHEMBL15617723 0.82 BCL2 (0.38) PIK3CDBCL2CSNK2A2CSNK2BDGAT2
SCHEMBL2017931 0.82 SLC22A12 (0.41) PIK3CDBCL2CSNK2A2CSNK2BDGAT2
SCHEMBL2019258 0.80 PIK3CD (0.58) PIK3CDBCL2NT5EKCNH2GCGR
SCHEMBL2163762 0.80 PIK3CD (0.58) PIK3CDBCL2NT5EKCNH2GCGR
SCHEMBL2014653 0.76 CSNK2A2 (0.39) CSNK2A2CSNK2BDGAT2SLC22A12NT5E
SCHEMBL2035181 0.75 PIK3CD (0.40) PIK3CDBCL2NT5EKCNH2GRIN2B
SCHEMBL2019120 0.74 PIK3CD (0.60) PIK3CDBCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 — — WO disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS PIK3R1, PIK3R3, PIK3R2 PIK3CD 13/4885BCL2 1174/4885CSNK2A2 220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.