Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 4/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015154 | 0.88 | TAAR1 (0.41) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL2017932 | 0.81 | SLC22A12 (0.40) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL2019261 | 0.80 | PIK3CD (0.44) | CYP17A1CYP3A4CYP11B1CYP11B2NT5E | |
| SCHEMBL2014651 | 0.76 | PIK3CD (0.39) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL2015153 | 0.74 | BCL2 (0.41) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL2012666 | 0.72 | TAAR1 (0.47) | NT5E | |
| SCHEMBL15621376 | 0.71 | PIK3CD (0.38) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL12470054 | 0.71 | PIK3CD (0.38) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 | |
| SCHEMBL2016661 | 0.70 | PIK3CD (0.36) | CYP17A1CYP3A4CYP11B1CYP11B2ADORA1 | |
| SCHEMBL15617723 | 0.69 | BCL2 (0.38) | CSNK2A2CSNK2BCYP17A1CYP3A4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |