Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288797 | 0.83 | MKNK1 (0.64) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL19243724 | 0.80 | MKNK1 (0.61) | MKNK1MKNK2CYP3A4EIF4EEGLN2 | |
| SCHEMBL20146864 | 0.78 | MKNK1 (0.66) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL15288515 | 0.73 | MKNK1 (0.84) | MKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL15285853 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL15298897 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL16304120 | 0.72 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL15288317 | 0.72 | MKNK1 (0.62) | MKNK1MKNK2CYP3A4EIF4ECHRM4 | |
| SCHEMBL15298892 | 0.72 | MKNK1 (0.52) | MKNK1MKNK2CYP3A4EIF4ENTRK1 | |
| SCHEMBL15288399 | 0.71 | MKNK1 (0.69) | MKNK1MKNK2CYP3A4EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |