Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | EIF4E | P06730 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19243847 | 0.89 | MKNK1 (0.55) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL19243715 | 0.88 | MKNK1 (0.66) | MKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL20146929 | 0.85 | MKNK1 (0.52) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL19243768 | 0.85 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL20146796 | 0.82 | MKNK1 (0.58) | MKNK1MKNK2CYP3A4FYN | |
| SCHEMBL20418033 | 0.81 | MKNK1 (0.71) | MKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL15286459 | 0.80 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL20146782 | 0.78 | MKNK1 (0.54) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL15298890 | 0.77 | MKNK1 (0.74) | MKNK1MKNK2CYP3A4EIF4E | |
| SCHEMBL15288441 | 0.77 | MKNK1 (0.93) | MKNK1MKNK2CYP3A4EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |