Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 19/20 | 0.84 |
| ▸ | MKNK2 | Q9HBH9 | 19/20 | 0.84 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152604 | 0.91 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL19243864 | 0.89 | MKNK1 (0.81) | MKNK1MKNK2ATM | |
| SCHEMBL19243707 | 0.89 | MKNK1 (0.81) | MKNK1MKNK2 | |
| SCHEMBL20146870 | 0.89 | MKNK1 (0.82) | MKNK1MKNK2 | |
| SCHEMBL19243748 | 0.89 | MKNK1 (0.79) | MKNK1MKNK2 | |
| SCHEMBL19243808 | 0.88 | MKNK1 (0.81) | MKNK1MKNK2ATM | |
| SCHEMBL19243749 | 0.88 | MKNK1 (0.78) | MKNK1MKNK2 | |
| SCHEMBL31554 | 0.86 | MKNK1 (0.63) | MKNK1MKNK2 | |
| SCHEMBL20975994 | 0.86 | MKNK1 (0.80) | MKNK1MKNK2 | |
| SCHEMBL15288106 | 0.83 | MKNK1 (1.00) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |