Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 18/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 18/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288106 | 0.91 | MKNK1 (1.00) | MKNK1MKNK2FYN | |
| SCHEMBL18012889 | 0.91 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4FYN | |
| SCHEMBL20146791 | 0.91 | MKNK1 (0.84) | MKNK1MKNK2 | |
| SCHEMBL16291078 | 0.90 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4FYN | |
| SCHEMBL19243808 | 0.90 | MKNK1 (0.81) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL19243707 | 0.89 | MKNK1 (0.81) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL19243864 | 0.89 | MKNK1 (0.81) | MKNK1MKNK2 | |
| SCHEMBL15285845 | 0.89 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4FYN | |
| SCHEMBL19243748 | 0.89 | MKNK1 (0.79) | MKNK1MKNK2FYN | |
| SCHEMBL15288575 | 0.88 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190211020-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190211020-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | MAPKAPK2, NEK2, MKNK2 | MKNK1 6/4885MKNK2 3/4885CYP3A4 3519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.