Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.58 |
| ▸ | FYN | P06241 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19243847 | 0.90 | MKNK1 (0.55) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL20146864 | 0.82 | MKNK1 (0.66) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL19243768 | 0.81 | MKNK1 (0.51) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL15288190 | 0.80 | MKNK1 (0.83) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL19243866 | 0.79 | MKNK1 (0.70) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL20146786 | 0.77 | MKNK1 (0.54) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL15288581 | 0.75 | MKNK1 (0.79) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL15288575 | 0.74 | MKNK1 (1.00) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL20146865 | 0.73 | MKNK1 (0.44) | MKNK1MKNK2CYP3A4 | |
| SCHEMBL15286159 | 0.73 | MKNK1 (0.80) | MKNK1MKNK2FYNCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |