Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 17/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 17/20 | 0.56 |
| ▸ | EIF4E | P06730 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291305 | 0.84 | MKNK1 (0.68) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL19243715 | 0.80 | MKNK1 (0.66) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL15288199 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL15288470 | 0.77 | MKNK1 (0.50) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL15288559 | 0.77 | MKNK1 (0.70) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL15286279 | 0.76 | MKNK1 (0.69) | MKNK1MKNK2EIF4ECYP3A4RAD52 | |
| SCHEMBL15288359 | 0.76 | MKNK1 (0.56) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL16304115 | 0.74 | MKNK1 (0.76) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL15288054 | 0.74 | MKNK1 (0.53) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL15288395 | 0.73 | MKNK1 (0.75) | MKNK1MKNK2EIF4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |