Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 18/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 18/20 | 0.66 |
| ▸ | EIF4E | P06730 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20146864 | 0.88 | MKNK1 (0.66) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20146929 | 0.85 | MKNK1 (0.52) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20146857 | 0.80 | MKNK1 (0.56) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL19243879 | 0.80 | MKNK1 (0.62) | MKNK1MKNK2EIF4ECYP3A4NTRK1 | |
| Tinodasertib SCHEMBL15288605 | 0.80 | MKNK1 (1.00) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20418033 | 0.80 | MKNK1 (0.71) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL19243847 | 0.77 | MKNK1 (0.55) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL16297316 | 0.77 | MKNK1 (0.93) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL20146865 | 0.76 | MKNK1 (0.44) | MKNK1MKNK2EIF4ECYP3A4NTRK1 | |
| SCHEMBL15298897 | 0.76 | MKNK1 (0.51) | MKNK1MKNK2EIF4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831079-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2017-08-16 | — | — | EP | disclosed |