Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | EIF4E | P06730 | 1/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19243695 | 0.85 | MKNK1 (0.60) | MKNK1MKNK2CYP3A4FYN | |
| SCHEMBL18609486 | 0.83 | MKNK1 (0.57) | MKNK1MKNK2CYP3A4EIF4EPRMT5 | |
| SCHEMBL15288077 | 0.81 | MKNK1 (0.68) | MKNK1MKNK2CYP3A4EIF4EPIK3CA | |
| SCHEMBL19243881 | 0.80 | MKNK1 (0.57) | MKNK1MKNK2CYP3A4EIF4EPRMT5 | |
| SCHEMBL14852149 | 0.78 | PIK3CA (0.48) | MKNK1MKNK2PIK3CAKCNH2MTOR | |
| SCHEMBL15288730 | 0.78 | MKNK1 (0.52) | MKNK1MKNK2CYP3A4EIF4EPRMT5 | |
| SCHEMBL19243751 | 0.78 | MKNK1 (0.61) | MKNK1MKNK2CYP3A4KCNH2SRC | |
| SCHEMBL3189884 | 0.75 | HDAC2 (0.53) | HDAC2 | |
| SCHEMBL15288297 | 0.75 | MKNK1 (0.63) | MKNK1MKNK2CYP3A4EIF4EPRMT5 | |
| SCHEMBL15288375 | 0.74 | MKNK1 (0.80) | MKNK1MKNK2CYP3A4EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |