Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784675 | 0.87 | POLB (0.37) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL20219320 | 0.83 | POLB (0.34) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL20219271 | 0.81 | ALDH1A1 (0.41) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL6730684 | 0.81 | POLB (0.36) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL769470 | 0.79 | ALDH1A1 (0.38) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL769472 | 0.77 | ALDH1A1 (0.36) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL769471 | 0.77 | ALDH1A1 (0.36) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL22754449 | 0.77 | ALDH1A1 (0.35) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL19393806 | 0.76 | HTT (0.40) | POLBHTTTDP1ALDH1A1CYP3A4 | |
| SCHEMBL19393875 | 0.75 | POLB (0.37) | POLBHTTTDP1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408749-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2018-05-16 | — | — | EP | disclosed |