Sugi Predict

Sugi Predict / Compounds / SCHEMBL20147360

SCHEMBL20147360

SCHEMBL20147360

CC(C)N1CCC(Cc2ccccc2)(CN(C)CC(=O)N(C)C)CC1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 1/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ HRH3 Q9Y5N1 2/20 0.40
▸ CHRM1 P11229 2/20 0.39
▸ OPRM1 P35372 5/20 0.39
▸ OPRL1 P41146 5/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ KCNH2 Q12809 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.37
▸ OPRD1 P41143 1/20 0.37
▸ OPRK1 P41145 1/20 0.37
▸ NPFFR1 Q9GZQ6 1/20 0.37
▸ NPFFR2 Q9Y5X5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20069534 0.88 RET (0.47) RETMEN1KMT2AOPRM1OPRL1
SCHEMBL20158623 0.86 RET (0.46) RETMEN1KMT2AOPRM1OPRL1
SCHEMBL22857081 0.84 RET (0.44) RETMEN1KMT2ACHRM1OPRM1
SCHEMBL20147359 0.82 MEN1 (0.49) RETMEN1KMT2AHRH3CHRM1
SCHEMBL20147379 0.81 OPRL1 (0.45) RETMEN1KMT2AHRH3OPRM1
SCHEMBL20147388 0.81 RET (0.46) RETMEN1KMT2AHRH3CHRM1
SCHEMBL20147413 0.76 MEN1 (0.69) MEN1KMT2ACYP2D6GAAALDH1A1
SCHEMBL20069555 0.74 CYP2D6 (0.32) HRH3OPRM1OPRL1CYP2D6
SCHEMBL20147305 0.74 HRH3 (0.31) HRH3OPRM1OPRL1
SCHEMBL14507968 0.71 OPRM1 (0.54) MEN1KMT2AHRH3CHRM1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885MEN1 653/4885KMT2A 1112/4885
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 RET 1/4885MEN1 653/4885KMT2A 1112/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885MEN1 653/4885KMT2A 1112/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885MEN1 653/4885KMT2A 1112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.