Sugi Predict

Sugi Predict / Compounds / SCHEMBL20147664

SCHEMBL20147664

SCHEMBL20147664

CC(C)N1CCC(NC(=O)c2ncccc2Cl)C(O)C1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 6/20 0.45
▸ DYRK1A Q13627 1/20 0.41
▸ CNR1 P21554 2/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ F10 P00742 2/20 0.38
▸ HTR3E A5X5Y0 2/20 0.38
▸ HTR3B O95264 2/20 0.38
▸ HTR3A P46098 2/20 0.38
▸ HTR3D Q70Z44 2/20 0.38
▸ HTR3C Q8WXA8 2/20 0.38
▸ HRH3 Q9Y5N1 1/20 0.38
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ HTR4 Q13639 1/20 0.37
▸ TRPV4 Q9HBA0 1/20 0.37
▸ ACKR3 P25106 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20147997 0.92 RET (0.44) RETDYRK1ACNR1MEN1KMT2A
SCHEMBL20147671 0.89 RET (0.46) RETDYRK1AMEN1KMT2AF10
SCHEMBL20147670 0.88 RET (0.43) RETDYRK1AHRH3CYP3A4CYP2D6
SCHEMBL20147666 0.86 RET (0.47) RETDYRK1AHTR3EHTR3BHTR3A
SCHEMBL20068971 0.85 RET (0.46) RETCNR1MEN1KMT2A
SCHEMBL20147608 0.85 HRH3 (0.52) DYRK1AMEN1KMT2AF10HRH3
SCHEMBL20147668 0.84 RET (0.47) RETHRH3
SCHEMBL21651925 0.83 RET (0.46) RETCNR1MEN1KMT2AHTR3E
SCHEMBL20147919 0.78 HTR4 (0.45) RETCNR1F10HTR4
SCHEMBL20147600 0.78 RET (0.45) RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885DYRK1A 231/4885CNR1 3827/4885
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 RET 1/4885DYRK1A 231/4885CNR1 3827/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885DYRK1A 231/4885CNR1 3827/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885DYRK1A 231/4885CNR1 3827/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.