Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014148 | 0.91 | PIK3CD (0.47) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2016210 | 0.91 | PIK3CD (0.55) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2016719 | 0.89 | PIK3CD (0.47) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2016846 | 0.89 | PIK3CD (0.45) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2013295 | 0.86 | PIK3CD (0.53) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| Trifluoroacetic Acid SCHEMBL2052106 | 0.85 | PIK3CD (0.42) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2051140 | 0.83 | PIK3CD (0.45) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2015901 | 0.81 | MAPK1 (0.48) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2016865 | 0.81 | PIK3CD (0.56) | PIK3CDSYKMAP4K4LMNAMAPK1 | |
| SCHEMBL2052089 | 0.81 | PIK3CD (0.48) | PIK3CDSYKMAP4K4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |