Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051059 | 0.95 | PIK3CD (0.53) | PIK3CDBCL2MAP4K4AXLMERTK | |
| SCHEMBL2012486 | 0.92 | PIK3CD (0.46) | PIK3CDBCL2LMNAMAPK1HTT | |
| SCHEMBL2012713 | 0.91 | PIK3CD (0.55) | PIK3CDBCL2MAP4K4AXLMERTK | |
| SCHEMBL2016719 | 0.91 | PIK3CD (0.47) | PIK3CDBCL2MAP4K4AXLMERTK | |
| SCHEMBL2052089 | 0.90 | PIK3CD (0.48) | PIK3CDBCL2MAP4K4AXLMERTK | |
| SCHEMBL2016210 | 0.90 | PIK3CD (0.55) | PIK3CDBCL2MAP4K4AXLMERTK | |
| SCHEMBL2051140 | 0.87 | PIK3CD (0.45) | PIK3CDBCL2MAP4K4AXLMERTK | |
| Trifluoroacetic Acid SCHEMBL2038097 | 0.85 | PIK3CD (0.49) | PIK3CDBCL2MAP4K4PIK3CGCLK4 | |
| SCHEMBL2050306 | 0.85 | PIK3CD (0.42) | PIK3CDBCL2CLK4AURKADYRK1A | |
| SCHEMBL2012817 | 0.84 | PIK3CD (0.42) | PIK3CDBCL2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129021-A1 | TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR | Incyte Corporation (US) | 2017-02-15 | — | — | EP | claimed |
| WO-2015157257-A1 | TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR | INCYTE CORPORATION (US) | 2015-10-15 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |