Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | PDE5A | O76074 | 12/20 | 0.56 |
| ▸ | GUCY1A1 | Q02108 | 6/20 | 0.54 |
| ▸ | GUCY1B1 | Q02153 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255818 | 0.90 | ADORA3 (0.65) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15127590 | 0.89 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL174210 | 0.89 | ADORA3 (0.64) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL29154434 | 0.89 | ADORA3 (0.68) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL174847 | 0.88 | ADORA3 (0.67) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL23434879 | 0.88 | ADORA3 (0.67) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL255851 | 0.88 | ADORA3 (0.62) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL18212217 | 0.88 | ADORA3 (0.70) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL1930775 | 0.87 | ADORA3 (0.66) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| Hydrochloric Acid SCHEMBL18496411 | 0.87 | ADORA3 (0.66) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089328-A1 | TREATMENT OF CNS DISEASES WITH SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| CN-105367568-A | Riociguat preparation method | ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD | 2016-03-02 | — | — | CN | disclosed |
| CN-105367568-A | Riociguat preparation method | ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD | 2016-03-02 | — | — | CN | disclosed |
| CN-105367567-A | Compound and application thereof in preparation of riociguat | ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD | 2016-03-02 | — | — | CN | disclosed |
| CN-105367567-A | Compound and application thereof in preparation of riociguat | ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD | 2016-03-02 | — | — | CN | disclosed |