SCHEMBL20149080

SCHEMBL20149080

CC(=O)N1CCN(C(=O)N2CC(c3ccc(C(OCc4c(F)cccc4F)(C(F)(F)F)C(F)(F)F)cc3)[C@H]([S+]([O-])c3ccc(F)c(-c4cnn(C)c4)c3)C2)CC1

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20149077 0.86 RORC (1.00) RORC
SCHEMBL20149078 0.86 RORC (0.73) RORC
SCHEMBL20149306 0.85 RORC (0.73) RORC
SCHEMBL20149034 0.85 RORC (0.73) RORC
SCHEMBL23683602 0.76 RORC (1.00) RORC
SCHEMBL20149069 0.76 RORC (1.00) RORC
SCHEMBL20140407 0.73 RORC (1.00) RORC
SCHEMBL20140238 0.73 RORC (1.00) RORC
SCHEMBL20149119 0.73 RORC (1.00) RORC
SCHEMBL20149308 0.73 RORC (1.00) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089406-A1 ROR GAMMA MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-05-17 WO disclosed