Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.53 |
| ▸ | CALCA | P06881 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133638 | 0.80 | MTOR (0.77) | MTORRPTORMLST8CALCATRPV1 | |
| SCHEMBL20133811 | 0.73 | MTOR (0.41) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL22187996 | 0.70 | MTOR (0.65) | MTORRPTORMLST8CALCATRPV1 | |
| SCHEMBL20141082 | 0.70 | MTOR (0.45) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20149922 | 0.69 | MTOR (0.56) | MTORRPTORMLST8ALDH1A1PHGDH | |
| SCHEMBL20141600 | 0.68 | MAPT (0.49) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20149902 | 0.67 | MTOR (0.72) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL21360385 | 0.67 | MTOR (0.72) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL21360325 | 0.65 | MTOR (0.68) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20141200 | 0.65 | MTOR (0.68) | MTORRPTORMLST8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |