Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133669 | 0.86 | MTOR (0.59) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20133664 | 0.73 | MTOR (0.61) | MTORRPTORMLST8SYK | |
| SCHEMBL20150152 | 0.72 | MTOR (0.67) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20141354 | 0.69 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1SMN1; SMN2 | |
| SCHEMBL20133655 | 0.69 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1SMN1; SMN2 | |
| SCHEMBL20133545 | 0.69 | MTOR (0.68) | MTORRPTORMLST8ALDH1A1SMN1; SMN2 | |
| SCHEMBL22693232 | 0.69 | MTOR (0.47) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL22187867 | 0.68 | MTOR (0.60) | MTORRPTORMLST8SYK | |
| SCHEMBL20141160 | 0.68 | MTOR (0.51) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL21360293 | 0.68 | MTOR (0.81) | MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |