Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.69 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.69 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.69 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150021 | 0.92 | MTOR (0.70) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL22187975 | 0.85 | MTOR (0.75) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL22693274 | 0.85 | MTOR (0.67) | MTORRPTORMLST8DRD2TACR3 | |
| SCHEMBL22693272 | 0.85 | MTOR (0.67) | MTORRPTORMLST8PHGDHGPR6 | |
| SCHEMBL20133657 | 0.85 | MTOR (0.84) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL20133659 | 0.85 | MTOR (0.74) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL20133676 | 0.85 | MTOR (0.74) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL20133662 | 0.84 | MTOR (0.65) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL22188079 | 0.83 | MTOR (0.73) | MTORRPTORMLST8GRM5PHGDH | |
| SCHEMBL20133660 | 0.82 | MTOR (0.72) | MTORRPTORMLST8PHGDHGPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |