Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20149868 | 0.91 | MTOR (0.67) | MTORRPTORMLST8GPR119NSD2 | |
| SCHEMBL20149875 | 0.86 | MTOR (0.56) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20149922 | 0.85 | MTOR (0.56) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20129666 | 0.82 | MTOR (0.62) | MTORRPTORMLST8ALDH1A1NPC1 | |
| SCHEMBL20133739 | 0.82 | MTOR (0.78) | MTORRPTORMLST8ALDH1A1L3MBTL1 | |
| SCHEMBL20129637 | 0.82 | MTOR (0.64) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20133537 | 0.81 | MTOR (0.66) | MTORRPTORMLST8GPR119BRD4 | |
| SCHEMBL20133558 | 0.81 | MTOR (0.66) | MTORRPTORMLST8GPR119BRD4 | |
| SCHEMBL20133681 | 0.80 | MTOR (0.65) | MTORRPTORMLST8ALDH1A1L3MBTL1 | |
| SCHEMBL20150218 | 0.79 | MTOR (0.74) | MTORRPTORMLST8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |