Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.56 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129599 | 0.93 | MTOR (0.66) | MTORRPTORMLST8P2RY12DRD2 | |
| SCHEMBL20149927 | 0.86 | MTOR (0.56) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20133534 | 0.85 | MTOR (0.60) | MTORRPTORMLST8P2RY12KDM4E | |
| SCHEMBL20141237 | 0.85 | MTOR (0.60) | MTORRPTORMLST8P2RY12KDM4E | |
| SCHEMBL20141219 | 0.84 | MTOR (0.68) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20141480 | 0.83 | MTOR (0.78) | MTORRPTORMLST8DPP4 | |
| SCHEMBL20133710 | 0.82 | MTOR (0.67) | MTORRPTORMLST8P2RY12PHGDH | |
| SCHEMBL20133774 | 0.82 | MTOR (0.67) | MTORRPTORMLST8P2RY12PHGDH | |
| SCHEMBL21340087 | 0.80 | MTOR (0.78) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20149922 | 0.79 | MTOR (0.56) | MTORRPTORMLST8PHGDHDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |